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Sanango




TABERNAEMONTANA UNDULATA:
Family: Apocynaceae
Genus: Tabernaemontana
Species: T. undulata
Origin: Ecuador
Common names: Tabernaemontana undulata extract, Sananga, Becchete, Bëcchëte, Milkwood
AKA: Uchu Sanango (Tabernaemontana Sananho) also known as Abuelo Sanango or Grandfather Sanango.
Chiric Sanango (Brunfelsia grandiflora) 
Ingredients: Tabernaemontana Undulate. (Yawanawán: Kanapa Vêtxexeni)
Care: Sananga is best kept refrigerated (but not frozen) and has a shelf life of about 6 months. 

Sananga eye drops contain an abundance of alkaloids, whereof the most potent active ingredient is ibogaine, which has long lasting and powerful effects on your mind, enabling powerful introspection and re-alignment. Apart from ibogaine, several other alkaloids, such as coronaridine, quebrachidine, heyneanine, 3-hydroxycoronaridine, ibogamine and voacangine are contained in Sananga. All of these alkaloids have powerful psychoactive effects and can exert strong antibiotic effects.

There can be slight differences in the composition of Sananga: the Becchete from the Matsés tribe contains Tabernaemontana undulata roots, whereas the Sananga eye drops from the Kaxinawá tribe contains sananho roots. Both of these roots are known to produce strong vision.

'Sananga' - (Amazonian Spiritual Eye Medicine)
"These eye drops comes from a potato bush from Amazon and is not psychoactive, but promotes improves in the capacity of vision, (the vision becomes more accurate) extending the connection to the spiritual. Sananga corrects optical imperfections in energy level. Sananga cleans the cornea and retina, many notice better vision after use. On an energetic level Sananga works very similarly to Rapé, cleaning the energy field and aligning the spirit on a molecular and cellular level."
-http://kjepakaj.blogspot.com/p/huni-kuin-traditional.html
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SANANGA A MEDICINA DA FLORESTA PARA O OLHO

Sananga Eye Drops
These eye drops comes from a potato bush from Amazon and is not psychoactive, but promotes improves in the capacity of vision, (the vision becomes more accurate) extending the connection to the spiritual. Sananga corrects optical imperfections in energy level. Sananga cleans the cornea and retina, many notice better vision after use. On an energetic level Sananga works very similarly to Rapé, cleaning the energy field and aligning the spirit on a molecular and cellular level.

Sananga Eye Drops
Sananga is made from the roots and bark of the Tabernaemontana undulata shrub. The root and bark of this plant are obtained from the Kaxinawá and Yawanawá tribe, This sacred and potent medicine is used for healing physical and spiritual ailments, by clearing the mind and energies and gaining a complete new way of perception and focus.

Sananga is made from the roots and bark of the Tabernaemontana undulata shrub a "milkwood" species in the family Apocynaceae, and comes directly from the Amazonian tribes peoples. This sacred and potent medicine is used for healing physical and spiritual ailments, by clearing the mind of distractive energies and allowing for a complete new way of perceiving and focusing. This Sananga is infused with intentions of absolute clarity and focus. Although Sananga is said to contain Ibogaine alkaloids there is actually little evidence to suggest this is in fact true. Tabernaemontanta is not actually a genus but a "sub-family", and therefore also classified as "Tabernaemontanoidae". McKenna reports that only some of the several dozen or so plants in this sub family contain ibogaine, others like ‘undulata' may only have analgesic or sedative properties.

Usage and Medicinal Effects
The pure spirit of Sananga supports a deep cleansing of blocked energies on emotional, physical, and spiritual levels. Sananga can balance and increase your energies, and find the roots of your diseases and blockages, leading to a complete equilibrium, focus and peace of mind. Moreover, the drops will expand your spiritual vision and awareness, and enhance your ability to read others people´s intentions. Also, Sananga increases your long-range vision, which is important for visualizations and predictions of the future. Apart of this, the drops are also used to cure and improve a broad range of ocular problems (Lambert et al 2010), like myopia, depth and color perception, definition of images, and detection accuracy. Furthermore, this magical medicine is indicated in cases of severe eye diseases, such as glaucoma, cataract, and blindness. As these drops can exert such powerful effects on your visualization, they are also commonly applied before or during Ayahuasca ceremonies, to increase visualization and spiritual insights.

Even though Sananga is famous for its effects on vision and visualization, this medicine is considered to be an indigenous all-purpose remedy. It is applied for febrifuge, emetic, diuretic, calmative, and several other diseases. Furthermore, Sananga is often used to cure skin illnesses (dermatitis), suppress appetite (Jernigan 2009), ease dental problems (Shepard 1999), and counteract snakebite wounds and poisoning, cure eye wounds and rheumatism (Sanz-Biset et al. 2009; Schultes 1979). Another important curative aspect of the Apocynaceae family is its widely explored antimicrobial activity, which showed that this family has strong antioxidant (Pereira et al. 2005), anticancer (Kingston et al. 1977; Gunasekera et al. 1980), antifertility/ contraceptive (Meyeret al. 1973), antipyretic (fever reducing), anti-inflammatory (Taesotikul et al. 2003), anti-mycobacterial (Pereira et al. 2005), and antimicrobial (Beek et al. 1984; Suffredini et al. 2002; Ruttoh et al. 2009) effects.

Traditionally, tribes like the Matsés use Sananga as a hunting tool to obtain a sharp perception and concentration, and to enable the detection of subtle movements in the dark jungle (Lambert et al 2010). Moreover, the drops can enable strong visualizations of the prey or the plant to be hunted, allowing for a quick and successful quest. Often Sananga is combined with other hunting tools, like Kambo, which further enhance the hunting skills. For most indigenous tribes, hunting means survival and therefore signifies an exceptionally important and crucial ability.

There can be slight differences in the composition of Sananga: the Becchete from the Matsés tribe contains Tabernaemontana undulata roots, whereas the Sananga eye drops from the Kaxinawá tribe contains Kunakip (Tabernaemontana sananho) roots. Both of these roots are known to produce strong vision (waimatai) that are very useful for successful hunting (Jernigan 2009).

Spiritual Understandings:

Traditionally Sananga has been used by the indigenous tribes of Brazil for hunting within the Amazon jungle to feed their families and tribes. To help sharpen their vision, awareness and extra sensory perceptions to stay focused and strong. In this way we can apply this to our life. Using these sacred drops to heal what they call Panema. Lack of drive, motivation or focus, laziness, depression, sadness, bad luck and negative energetic influences that attract difficulties and disease.

Improves the vision, extending the connection into the spiritual realms. On an energetic level Sananga works to open up the inner vision of the third eye, helps to decalcify and activate the pineal gland. Clears negative thought patterns and mental confusion. Cleansing the physical, emotional and energetic fields, Sananga aids in aligning and cleansing the chakras and the aura while removing negative entities and energies.

Sananga helps to cleans on very deep levels and is such a beautiful powerful plant to work with. Many have noticed an increase in the capacity for their vision improving physically and energetically after the use of Sananga.

These sacred eye drops come directly from the Yawanawa Tribe that live close to nature and all her creatures upon the bed of the Amazonian Jungle in Acre, Brazil.

Dose
Before thinking about the dose, you should read carefully our thoughts on the power of your intention: every medicine can only achieve and cure what you are intending.
Only one drop per eye is enough for a powerful Sananga session. We recommend to find a calm and quiet place, either in nature, or at home in a peaceful setting and with meditative music. The acute effects will wear off after 10-15 min, yet subtle after effects can last for days. Make sure you lie down to enable a good application and leave your eyes closed during the session. It is important to apply one drop to both eyes, and do not wait with the second drop, apply it immediately to balance out the energies on both eyes. Thereafter, you should blink with your eyelids for a short while to distribute the liquid over the whole eye. Ideally, you find a second person who can apply the Sananga for you.

Shortly after the application to the eyes, most users report a strong burning and intense prickly pain sensation. Yet, these effects reside after a few minutes, and can be alleviated by focusing on your breathing and by visualizing how the pain removes your blocked energies and brings deep healing. Moreover, you may also experience vomiting and bowel movements, which are further indications for the removal of blocked energies and illness. Try to surrender fully and relax as much as possible.
Similar to the iboga micro dosing, you can apply Sananga on a daily base but you should adhere to our protocol and stick to strong intentions of healing to achieve profound results.

Cautions
Contact lenses should be removed before applying Sananga.
1 eyar after eye surgery

Storage
Please keep the bottle refrigerated, the ingredients are very fragile and can easily decompose and catch molds or fungi.
Tabernaemontana sananho
Alkaloid info and pharmacology (Van Beek et al 1984)
Coronoaridine
CAS: 467-77-6
338.44 g/mol
The alkaloid has been tested in the mouse, cat, dog, monkey and rat by a variety of pharmacological procedures. It showed autonomic and CNS activity. In mice it produced analgesia and was effective in suppressing rage caused by foot-shock. Toxicity in the anesthetised cat appeared to be associated with respiratory depression. Coronaridine was inactive in the 9 KB system in cell culture [ 150]. In a general pharmacological screening, the compound exhibited little activity [164]. A single 30 mg/kg p.o. dose of coronaridine prevented pregnancy in rats when given on day 1, 2, 3 or 4 after coitus. When given on day 5, 6, 7 or 8 of pregnancy, the results were only partially successful. The substance showed estrogenic activity, and it was this activity which appeared to be responsible for the antifertility action. However, the alkaloid was devoid of anti-estrogenic, androgenic, anti-androgenic, progestational, anti-progestational and uterine-stimulant

3-hydroxy-Coronaridine
CAS: 56867-69-7
354.19 g/mol
The substance had strong antibiotic activity [ 382]

Ibogamine
CAS: 481-87-8
280.41 g/mol
Central-stimulating properties were observed in a general pharmacological screening, and in mice, when administered S.C. together with Rididyl i.p., the alkaloid produced jactatio capitis [164]. On iv. injection into anesthetised guinea pigs, the effects observed were the same as with ibogaine (q.v.) [221]. Ibogamine was not active in the P-388 or KB test systems in cell culture [ 353]

Voacangine
CAS: 510-22-5
368.21 g/mol
In a general pharmacological screening, voacangine exhibited a slight central stimulating effect. The LDSo i.v. in the mouse was 54 mg/kg [ 164]. When injected i.v. into anesthetised guinea pigs it produced the same effects as did ibogaine (q.v.) [221]. Voacangine had no effect on the heart [ 178]. The alkaloid was not active in the P-388 and KB test systems in cell culture
References

Beek VTA, Verpoorte R, Svendsen AB, Leeuwenberg AJ, Bisset NG (1984). Tabernaemontana L. (Apocynaceae): A review of its taxonomy, phytochemistry, ethnobotany and pharmacology. J Ethnopharmacol.;10(1):1-156.

Beek TAV, Kuijlaars FLC, Thomassen PM, Verpoorter R, Svendsen B (1984). Antimicrobially active alkaloids from Tabernaemontana pachysiphon. Phytochemistry, 23(8):1771–1778.

delle Monache G, de Matta SM, delle Monache F, Marini-Bettolo GB (1977) Atti Accademia Nazionale dei Lincei, Memorie, Classe di Science Fisiche, Matematiche et Natumli [viii] 62, 221.
Gunasekera SP, Cordell GA, Farnsworth N (1980). Anticancer INDOLE Alkaloids of Ervatamia heyneana. Phytochemistry, 19:1213–1218. 17.

Jernigan KA (2009). Barking up the same tree: a comparison of ethnomedicine and canine ethnoveterinary medicine among the Aguaruna. J Ethnobiol Ethnomed.; 5: 33.

Kingston DGI, Bernard TLI, Ioescu F (1977). Plant anticancer agents 111: isolation of indole and bisindole alkaloids from Tabernaemontana holstii roots. J Pharm Sci, 66(8):1135–1138. 16.

Koenig X, Hilber K (2015).The anti-addiction drug ibogaine and the heart: a delicate relation. Molecules.;20(2):2208-28.

Liu L, Cao JX, Yao YC, Xu SP (2013). Progress of pharmacological studies on alkaloids from Apocynaceae. J Asian Nat Prod Res.; 15(2):166-84.

Meyer WE, Coppola JA, Goldman L (1973). Alkaloid studies VIII. Isolation and characterization of alkaloids of Tabernaemontana heyneana and antifertility properties of coronaridine. J Pharm Sci, 62(7):1199–1201.

Pereira CG, Leal PF, Sato DN, Meireles MA (2005). Antioxidant and antimycobacterial activities of Tabernaemontana catharinensis extracts obtained by supercritical CO2 + cosolvent. J Med Food, 8(4):533–538.

Ruttoh EK, Bii C, Tarus PK, Machocho A, Karimi LK, Okemo P (2009). Antifungal activity of Tabernaemontana stapfiana Britten (Apocynaceae) organic extracts. Pharmacognosy Res, 1(6):387–391.

Sanz-Biset J, Campos-de-la-Cruz J, Epiquién-Rivera MA, Cañigueral S (2009). A first survey on the medicinal plants of the Chazuta valley (Peruvian Amazon). J Ethnopharmacol.;122(2):333-62.
Shepard G: Pharmacognosy and the Senses in Two Amazonian Societies. In PhD Dissertation University of California, Berkeley, Medical Anthropology Program; 1999.

Schultes RE (1979) Journal of Ethnopharmacology 1, 165.

Suffredini IB, Bacchi EM, Sakuda TK, Ohara MT, Younes RN, Varella AD (2002). Antibacterial activity of Apocynaceae extracts and MIC of Tabernaemontana angulata stem organic extract. Braz J Pharm Sci, 38(1):89–94. 23.

Taesotikul T, Panthong A, Kanjanapothi D, Verpoorte R, Scheffer JJC (2003). Anti-inflammatory, antipyretic and antinociceptive activities of Tabernaemontana pandacaqui Poir. J Ethnopharmacol, 84:31–35